Management of diabetic ketoacidosis in adult inpatients: A retrospective analysis of rates of hypoglycaemia with variable‐rate and fixed‐rate intravenous insulin infusion protocols
Authors' conclusion
There were similar rates of hypoglycaemia between VRIII and FRIII protocols; however, FRIII was associated with higher rates of early hypoglycaemia. Although time to resolution of ketosis was similar, VRIII was associated with longer hospital length of stay and time on insulin infusion. Further research is needed to determine the optimal insulin infusion regimen.
Study context
- Population
- Adult inpatients with DKA
- Participants
- 80 inpatients
- Exposure
- Variable-rate intravenous insulin infusion (VRIII) vs fixed-rate intravenous insulin infusion (FRIII) in DKA management
- VRIIIn = 45
- FRIIIn = 35reference
- Outcome
- Incidence of hypoglycaemia during DKA management
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
P = 0.565
Observational data: associations, not effects.
Secondary outcomes
Early hypoglycaemia (<12 h), share of those who developed it
P = 0.041
Time to resolution of ketosis · did not differ
P = 0.163
Time on insulin infusion · longer with VRIII
P = 0.018
Hospital LOS · longer with VRIII
P = 0.049
Original publication
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