Periodontal disease in adolescents with type 1 diabetes mellitus: A cross link between continuous glucose monitoring-derived metrics, caspase-3 levels, diabetic nephropathy and subclinical atherosclerosis
Authors' conclusion
Periodontitis is prevalent among adolescents with T1DM and is linked to glycemic variability and poor metabolic control while associated with diabetic nephropathy and subclinical atherosclerosis. Elevated caspase-3 highlights the involvement of apoptosis in periodontal disease and subclinical atherosclerosis in T1DM.
Study context
- Population
- Adolescents with T1D (15.91 ± 2.14 years)
- Exposure
- T1D with vs without periodontitis; T1D vs healthy controls
- Outcome
- Periodontitis prevalence in T1D
Main finding
As reported in the abstract
T1DM
69.6 %
Observational data: associations, not effects.
Further findings
T1DM vs Controls
Serum caspase-3 · significantly elevated in T1DM
P < 0.001
Periodontitis vs No periodontitis
GMI, periodontitis vs no periodontitis · higher with periodontitis
P = 0.047
CV, periodontitis vs no periodontitis · higher with periodontitis
P = 0.008
TIR, periodontitis vs no periodontitis · lower with periodontitis
P = 0.002
Other features with periodontitis
- Higher nephropathy percentage, elevated CIMT, caspase-3 and glycemic risk index with periodontitis vs without
Advanced HCL vs MDI
- Lower caspase-3 and CIMT with advanced hybrid closed loop vs MDI
Correlations of caspase-3
- Caspase-3 vs glucose management indicator (GMI), r
- 0.587
- Caspase-3 vs coefficient of variation (CV), r
- 0.434
- Caspase-3 vs CIMT, r
- 0.425
- Caspase-3 vs periodontal probing depths (PPD), r
- 0.952
- Caspase-3 vs CAL, r
- 0.739
- Caspase-3 vs time in range (TIR), r
- −0.481
- p < 0.001 for all
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
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