Infant gut microbiome composition correlated with type 1 diabetes acquisition in the general population: the ABIS study
Authors' conclusion
This investigation suggests that microbial biomarkers for type 1 diabetes may be present as early as 1 year of age, as reflected in the taxonomic and functional differences of the microbial communities. The possibility of preventing disease onset by altering or promoting a 'healthy' gut microbiome is appealing.
Study context
- Population
- Infants in the All Babies In Southeast Sweden (ABIS) general population cohort, stool sample at mean age 12.5 months32 matched controls per iteration
- Participants
- 16 vs 268
- Comparison
- Infants with future T1D vs healthy controls
- Future T1Dn = 16
- Healthy controlsn = 268reference
- Outcome
- Gut microbiome taxa associated with future T1D
- Follow-up
- Mean age 12.5 months
Methodological detailslongitudinal general population cohort, matched controls (100 iterations of 32 matched controls), 16S ribosomal RNA (rRNA) sequencing and quantitative PCR, PICRUSt functional prediction, random forest analysis
- Longitudinal general population cohort
- Matched controls (100 iterations of 32 matched controls)
- 16S rRNA sequencing and quantitative PCR
- PICRUSt functional prediction
- Random forest analysis
Main finding
As reported in the abstract
- Parasutterella and Eubacterium more abundant in healthy controls; Porphyromonas more abundant in future T1D
- Ruminococcus a strong determinant in random forest analysis, with differing trends of abundance between controls and future T1D
- Flavonifractor and UBA1819 strongest factors differentiating controls, with higher abundance in controls
- Alistipes (more abundant in controls) and Fusicatenibacter (mixed abundance patterns) strongest factors differentiating future T1D
Observational data: associations, not effects.
Further findings
- Predicted gene content for butyrate production and pyruvate fermentation higher in healthy controls
Original publication
Infant gut microbiome composition correlated with type 1 diabetes acquisition in the general population: the ABIS study. Diabetologia. Published 25 March 2023. doi:10.
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