Neonatal Diabetes in Ireland over the Past 19 Years: Clinical Presentation, Management, Genetics, and Outcomes
Authors' conclusion
This national case series highlights the genetic and phenotypic spectrum of NDM in Ireland. Early genetic diagnosis enables precision therapy, with timely sulphonylurea initiation improving outcomes in KATP-related NDM.
Study context
- Population
- Patients diagnosed with neonatal DM (onset before 6 months of age) in Ireland, 2006–2024
- Participants
- 19 patients
- Exposure
- PNDM vs TNDM
- PNDMn = 12
- TNDMn = 7
- Outcome
- Genetic diagnosis
Methodological details2006–2024
- 2006–2024
Main finding
As reported in the abstract
- PNDM: KCNJ11 variants
- 6
- PNDM: EIF2AK3 variants
- 3
- PNDM: INS variant
- 1
- PNDM: no genetic diagnosis
- 2
- TNDM: 6q24 methylation defects
- 6
- TNDM: ABCC8 variant
- 1
Observational data: associations, not effects.
Further findings
Age at diagnosis
- Age at diagnosis range
- 1 day to 11 months
Management
- Genetic diagnosis informed familial risk and prompted changes to a parent's medical management
- SU therapy was most effective when initiated early
Original publication
Neonatal Diabetes in Ireland over the Past 19 Years: Clinical Presentation, Management, Genetics, and Outcomes. Horm Res Paediatr. Published 3 February 2026. doi:10.
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