Prevalence and Presentation of Lower Limb Neurovascular Complications in Children With Diabetes: A Systematic Review With Proportion Meta‐Analysis
Authors' conclusion
The broad range may be due to heterogeneous methodological designs and diagnostic assessments, and potentially inadequate reporting. There is emerging evidence that children with diabetes may develop complications before age 18, which provides impetus for clinical caution.
Study context
- Population
- Children with diabetes aged 3.5–18 years; 95% T1D, 5% T2D
- Participants
- 3,533 children18 studies
- Outcome
- Prevalence and presentation of clinical neuropathy and vasculopathy
Methodological detailsproportion meta-analysis, Downs and Black quality appraisal, Search of EMBASE, Cochrane, PubMed (including MEDLINE) and CINAHL in March 2024
- Proportion meta-analysis
- Downs and Black quality appraisal
- Search of EMBASE, Cochrane, PubMed (including MEDLINE) and CINAHL in March 2024
Pooled result
As reported in the abstract
Prevalence of lower limb neurovascular complications
Prevalence of clinical neuropathy (range)
0% to 57.1%
Prevalence of vascular complications (range)
0% to 37.8%
Meta-analysis: children reporting abnormality on neuropathy assessments
0%-7%
Further pooled results
Change in clinical neuropathy prevalence in a prospective cohort study · 5 years
- Increase in prevalence of clinical neuropathy
- 2.6-fold
Original publication
Prevalence and Presentation of Lower Limb Neurovascular Complications in Children With Diabetes: A Systematic Review With Proportion Meta‐Analysis. Pediatr Diabetes. Published 23 June 2025. doi:10.
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