Sex differences in the risk of vascular and non-vascular complications in type 2 diabetes: the Fukuoka Diabetes Registry
Main finding · All-cause deathResult — go to the resultMultivariable-adjusted HR 0.61 95 % CI 0.46–0.82Authors' conclusion
The present study demonstrated sex differences in the risks of mortality, vascular and non-vascular complications, highlighting the importance of implementing sex-specific management approaches for patients with type 2 diabetes.
Study context
- Population
- Patients with T2D, Fukuoka Diabetes Registry
- Participants
- 4,923 patients
- Exposure
- Women vs men
- Outcome
- Hazard ratios (HRs) for mortality, macrovascular, microvascular and non-vascular complications in women vs men
Main finding
All-cause death
Multivariable-adjusted HR
0.61
95 % CI 0.46–0.82
Womenvs Men
multivariable-adjusted HR 0.61 (95 % CI 0.46–0.82)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | HR (95 % CI) | |
|---|---|---|
| Fracture | 2.04 (1.57–2.64) | |
| Microvascular eventsNo significant sex difference | 1.05 (0.81–1.35) | |
| 0.20.5125Hazard ratio (log scale) |
Major macrovascular events
- Lower risk in women vs men
- 50 % (95 % CI 25-67 %)
Cancer
- Lower risk in women vs men
- 42 % (95 % CI 26-54 %)
Absolute risk differences between sexes by age
- Increased with age, particularly for cancer and fracture
Original publication
Sex differences in the risk of vascular and non-vascular complications in type 2 diabetes: the Fukuoka Diabetes Registry. Diabetes Res Clin Pract. Published 21 June 2025. doi:10.
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