Transient Benign Ketosis Is Common in Type 1 Diabetes During Very-Low Carbohydrate States: Novel Data from Continuous Ketone Sensor
Authors' conclusion
SiBio ketone sensor demonstrated preliminary accuracy and reveals that benign, transient ketosis are common in type 1 diabetes during very-low carbohydrate states.
Study context
- Population
- Adults with T1D on AID wearing SiBio continuous ketone sensorscompleted the study
- Participants
- 16 adults
- Comparison
- Very-low carbohydrate diet vs intermittent 12-h fasting; ketone sensor vs capillary meter
Methodological detailstwo 6-day ketogenic diets in random order, insulin suspension experiment
- Two 6-day ketogenic diets in random order
- Insulin suspension experiment
Primary result
As reported in the abstract
Ketone sensor accuracy vs capillary meter (870 paired points)
Mean absolute difference (MAD) for ketone values <0.6 mmol/L
0.1 (0.1) mmol/L
Relative MAD for ketone values ≥0.6 mmol/L
24.2%
17.1
Relative MAD for ketone values ≥1.0 mmol/L
19.6%
13.3
Further findings
Ketosis events ≥0.6 mmol/L of >15 min during ketogenic diets (155 days)
- Ketosis events
- 81
- Event rate
- 3.7 events/week
- Median duration
- 60 (30-105) min/event
- Glucose levels, basal insulin delivery and time of day not related to ketosis events
Safety
Symptomatic ketosis
- All ketosis events except one were asymptomatic
Original publication
Transient Benign Ketosis Is Common in Type 1 Diabetes During Very-Low Carbohydrate States: Novel Data from Continuous Ketone Sensor. Diabetes Technol Ther. Published 15 January 2026. doi:10.
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