Transient Cognitive Vulnerability After Hypoglycemia in Adults With Type 1 Diabetes: Evidence From Continuous Glucose Monitoring and Cognitive Ecologic Momentary Assessment
Authors' conclusion
Hypoglycemia was associated with a transient period of cognitive vulnerability largely confined to the hour after an event, with little evidence of delayed effects. Findings support avoiding or exercising caution during cognitively demanding tasks for up to an hour after a hypoglycemic event.
Study context
- Population
- Adults with type 1 diabetes
- Participants
- 190 participants
- Outcome
- Processing speed and sustained attention (reaction time and performance on DSM and GCPT) after hypoglycemic events
- Follow-up
- 0-1 h before EMA
Methodological detailssmartphone-based, 15 days, 3 prompts/day, multilevel models
- Smartphone-based
- 15 days
- 3 prompts/day
- Multilevel models
Main finding
As reported in the abstract
0-1 h before EMA
- Hypoglycemic events occurring within 0-1 h of ecologic momentary assessment (EMA) were associated with slower reaction time and poorer performance on digit symbol matching (DSM) and GCPT
- Adjusted for age, EMA count, and interruptions
Further findings
Cognitive performance after hypoglycemic events · 1-2 or 2-3 h before EMA
- No associations were observed for events occurring 1-2 or 2-3 h before EMA
Cognition after hyperglycemic events and rapid glucose increases or decreases
- Not associated with cognition across most outcomes or time windows
Original publication
Transient Cognitive Vulnerability After Hypoglycemia in Adults With Type 1 Diabetes: Evidence From Continuous Glucose Monitoring and Cognitive Ecologic Momentary Assessment. Diabetes Care. Published 10 November 2026. doi:10.
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