Dynamic Relationships Among Continuous Glucose Metrics and Momentary Cognitive Performance in Diverse Adults With Type 1 Diabetes
Authors' conclusion
These novel observations of significant bidirectional association between glycemia and cognitive performance over the course of the day among adults with T1D emphasize the importance of examining within-person longitudinal effects over different time frames.
Study context
- Population
- Diverse adults with T1D (age 40 ± 14 years, 46% male, 41% Latino, 29% White, 15% Black)
- Participants
- 182 adults
- Outcome
- Bidirectional associations between CGM metrics and cognitive performance over sequential 3-h periods
- Follow-up
- 14 days
Methodological detailsblinded continuous glucose monitoring (CGM), ambulatory cognitive testing, dynamic structural equation models, Ambulatory tests of perceptual speed and sustained attention five or six times daily for 14 days
- Blinded CGM
- Ambulatory cognitive testing
- Dynamic structural equation models
- Ambulatory tests of perceptual speed and sustained attention five or six times daily for 14 days
Main finding
As reported in the abstract
14 days
- More time in low glucose over 3 h associated with slower perceptual speed at end of interval, not 3 h later
- P < 0.05
- More time in high glucose (>250 mg/dL) associated with faster perceptual speed initially but slower speed 3 h later
- P < 0.05
- Lower attention and higher perceptual speed predicted higher mean glucose and more time in very high glucose over the following 3 h
- P < 0.05
Observational data: associations, not effects.
Original publication
Dynamic Relationships Among Continuous Glucose Metrics and Momentary Cognitive Performance in Diverse Adults With Type 1 Diabetes. Diabetes Care. Published 31 March 2025. doi:10.
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