National Trends in US Hospitalizations and Outcomes of Thyrotoxicosis With and Without Thyrotoxic Storm, 2016 to 2020
Authors' conclusion
In the present study, we examined trends in hospilization and outcomes of thyrotoxicosis across the United States. Hospitalization rates for thyrotoxicosis were reduced while mortality rates significantly increased. There was an uptrend in health care costs, prolonged hospitalization, and the incidence of MACEs.
Study context
- Population
- US hospitalizations for thyrotoxicosis (ICD-10 E05), national inpatient database, 2016–2020
- Participants
- 33,430 hospitalizations
- Exposure
- Thyrotoxicosis hospitalizations with vs without thyroid storm; trends 2016 to 2020
- Outcome
- Hospitalization trends 2016 to 2020
- Follow-up
- 2016 to 2020
Methodological detailsnational inpatient database, ICD-10 codes, multivariable logistic regression
- National inpatient database
- ICD-10 codes
- Multivariable logistic regression
Main finding
As reported in the abstract
- Hospitalizations declined from 7444 in 2016 to 5424 in 2020
- Ptrend = .002
- Mortality without storm: 10 (0.17%) in 2016 to 55 (1.30%) in 2020
- Ptrend < .001
- Mortality with thyroid storm: 10 (0.62%) in 2016 to 50 (4.15%) in 2020
- Ptrend = .051
Observational data: associations, not effects.
Secondary outcomes
| Outcome | aOR (95% CI) | P value | |
|---|---|---|---|
| MACE | 1.05 (1.02–1.17) | P = 0.002 | |
| Acute HF | 1.15 (1.03–1.78) | P < 0.001 | |
| Sudden cardiac death | 1.23 (1.04–2.17) | P = 0.041 | |
| AF | 1.17 (1.05–2.06) | P < 0.001 | |
| 0.512Adjusted odds ratio (log scale) |
Prolonged hospitalization (95th percentile LOS), total cohort · 2016 to 2020
- 11.9% (3978) to 14.6% (4881)
- P for trend = 0.030
Total hospital costs (inflation-adjusted) · 2016 to 2020
- Total: $36 408 to 49 031
- P for trend < 0.001
- With storm: $45 343 to $69 321
- P for trend < 0.001
- Without storm: $34 066 to $42 703
- P for trend < 0.001
Original publication
National Trends in US Hospitalizations and Outcomes of Thyrotoxicosis With and Without Thyrotoxic Storm, 2016 to 2020. J Clin Endocrinol Metab. Published 11 March 2025. doi:10.
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