Twenty-year trend of thyrotoxicosis and thyrotoxic periodic paralysis: a population-based cohort study
Authors' conclusion
This is the first study establishing a TPP cohort based on validated clinical data from an electronic medical database. It is important to keep monitoring the increasing incidence rate of thyrotoxicosis.
Study context
- Population
- Thyrotoxicosis and thyrotoxic periodic paralysis (TPP) cases identified from a representative electronic medical database in Hong Kong, 2002–2021
- Participants
- 77,856 vs 994
- Exposure
- Thyrotoxicosis vs TPP
- Thyrotoxicosisn = 77,856
- TPPn = 994
- Outcome
- Standardized incidence rate of thyrotoxicosis and TPP and its trend
- Follow-up
- 2002 to 2021
Methodological detailselectronic medical database, validated case-identification algorithms
- Electronic medical database
- Validated case-identification algorithms
Main finding
As reported in the abstract
Age- and sex-standardized incidence rate of thyrotoxicosis (per 100,000 person-years)
- Thyrotoxicosis incidence in 2002
- 41.31
- Thyrotoxicosis incidence in 2021
- 69.51
- Average annual percentage change
- 4.77%
- TPP age-standardized incidence in males, 2002 and 2021
- 1.43 and 1.18
- TPP age-standardized incidence in females, 2002 and 2021
- 0.11 and 0.13
Observational data: associations, not effects.
Further findings
Algorithm validation: PPV for thyrotoxicosis and TPP
- PPV
- 0.86-0.97
- 200 randomly selected cases reviewed
TPP patient characteristics
- Male
- 93.66%
TPP-associated hospitalization rate and median length of stay (LOS) · 2002 to 2021
- TPP-associated hospitalization rate, steady
- 90.91-100%
- Median LOS, steady
- 2-3 days
Original publication
Twenty-year trend of thyrotoxicosis and thyrotoxic periodic paralysis: a population-based cohort study. Eur Thyroid J. Published 5 September 2025. doi:10.
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