Muscle and Liver Insulin Resistance Are Associated with Distinct Plasma Protein Profiles: Data from the DiOGenes Trial
Authors' conclusion
Understanding the processes underlying these distinct IR phenotypes could inform the development of personalized prevention strategies.
Study context
- Population
- Individuals with overweight or obesity, Diet, Obesity, and Genes (DiOGenes) cohort
- Participants
- 535 individuals
- Exposure
- Muscle insulin resistance (IR) vs liver IR: associated plasma proteins and pathways
- Outcome
- Plasma proteins and pathways associated with muscle IR and liver IR
Methodological detailsproteomic association analysis, adjusted for study center, sex, BMI and age, liver IR adjusted for muscle IR and vice versa, pathway enrichment analysis
- Proteomic association analysis
- Adjusted for study center, sex, BMI and age
- Liver IR adjusted for muscle IR and vice versa
- Pathway enrichment analysis
Main finding
As reported in the abstract
- Proteins associated with muscle IR
- 160
- Proteins associated with liver IR
- 81
- Proteins shared between both forms of IR
- 12
- Enriched pathways for muscle IR (strong inflammatory profile: chemokine signaling, interleukin-6 signaling, complement system-related)
- 51
- Enriched pathways for liver IR (primarily complement system)
- 11
Observational data: associations, not effects.
Original publication
Muscle and Liver Insulin Resistance Are Associated with Distinct Plasma Protein Profiles: Data from the DiOGenes Trial. J Clin Endocrinol Metab. Published 10 October 2025. doi:10.
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