Identification of circulating apolipoprotein M as a new determinant of insulin sensitivity and relationship with adiponectin
Authors' conclusion
The apoM rises as a new partner of adiponectin regarding insulin sensitivity. At the adipose tissue level, the adiponectin may be supported by apoM to promote a healthy adipose tissue.
Study context
- Population
- Men with overweight (cross-sectional); patients with obesity in a surgery-induced slimming program; adipose tissue from individuals with obesitymen with overweight
- Participants
- 169 men
- Exposure
- Circulating apolipoprotein M (apoM) vs adiponectin in relation to metabolic parameters and insulin sensitivity
- Outcome
- Associations of circulating apoM with HOMA-IR
Methodological detailssurgery-induced slimming program cohort, adipose tissue gene expression, human adipocyte cell line, 13 patients with obesity followed during a surgery-induced slimming program
- Surgery-induced slimming program cohort
- Adipose tissue gene expression
- Human adipocyte cell line
- 13 patients with obesity followed during a surgery-induced slimming program
Main finding
As reported in the abstract
apoM negatively associated with HOMA-IR and hs-CRP
r < −0.2
After surgery, change in HOMA-IR negatively associated with change in circulating apoM, not with change in adiponectin
r = −0.71
Observational data: associations, not effects.
Further findings
T2D and dyslipidaemia
- Participants with T2D had lower circulating adiponectin and apoM; apoM higher in individuals with dyslipidemia
Correlations with lipid markers, insulin and age
- apoM positively correlated with HDL markers (HDL-C and apoA-I)
- r > 0.3
- Unlike adiponectin, apoM positively associated with LDL markers (LDL-C and apoB100)
- r < 0.20
- Unlike adiponectin, apoM negatively correlated with insulin and age
- r < −0.2
APOM and ADIPOQ gene expression
- Positive correlation in adipose tissue
- r > 0.44
- Positive correlation in adipocytes
- r > 0.81
- In adipocytes, APOM downregulated by inflammatory factors and upregulated by adiponectin
- Adipose tissue from 267 individuals with obesity
Original publication
Identification of circulating apolipoprotein M as a new determinant of insulin sensitivity and relationship with adiponectin. Int J Obes (Lond). Published 15 March 2024. doi:10.
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