Adipose tissue insulin resistance, not muscle insulin resistance, is associated with impaired metabolic health in humans
Authors' conclusion
These findings demonstrate that adipose IR is more strongly and consistently linked to impaired metabolic health than muscle IR
Study context
- Population
- Adults aged 40–75 years, BMI 25–40 kg/m², PERSON study; categorized into four groups by indices of muscle and adipose insulin sensitivity
- Participants
- 229 adults
- Exposure
- Adipose insulin resistance (IR) vs muscle IR phenotypes
- Outcome
- Metabolic and clinical differences between adipose and muscle IR phenotypes
- Follow-up
- Baseline
Methodological detailsbaseline data of the PERSON study, Muscle IR assessed with 7-point OGTT; adipose IR from fasting plasma insulin and non-esterified fatty acids, Detailed phenotyping under controlled conditions and daily life
- Baseline data of the PERSON study
- Muscle IR assessed with 7-point OGTT; adipose IR from fasting plasma insulin and non-esterified fatty acids
- Detailed phenotyping under controlled conditions and daily life
Main finding
As reported in the abstract
Participants with discordant IR patterns
42%
Observational data: associations, not effects.
Original publication
Adipose tissue insulin resistance, not muscle insulin resistance, is associated with impaired metabolic health in humans. Diabetes Res Clin Pract. Published 2 August 2026. doi:10.
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