Circulating and adipose tissue immune cells in tissue‐specific insulin resistance in humans with overweight and obesity
Authors' conclusion
The present findings demonstrate that circulating immune cell populations and inflammatory gene expression in aSAT show distinct associations with liver and muscle insulin sensitivity.
Study context
- Population
- Individuals with overweight and obesity from the PERSON Study and the Maastricht Study (replication cohort)PERSON n = 219
- Outcome
- Associations of immune cells, aSAT gene expression and inflammatory markers with liver and muscle insulin sensitivity
Methodological detailsreplication cohort, Seven-point OGTT to assess liver and muscle insulin sensitivity; flow cytometry of circulating and abdominal subcutaneous AT (aSAT) immune cells and aSAT gene expression in subgroups
- Replication cohort
- Seven-point OGTT to assess liver and muscle insulin sensitivity; flow cytometry of circulating and aSAT immune cells and aSAT gene expression in subgroups
Main finding
As reported in the abstract
- Circulating T cells, nonclassical monocytes and CD56dim CD16+ natural killer cells inversely associated with liver, but not muscle, insulin sensitivity (PERSON Study)
- Inverse association between circulating (classical) monocytes and liver insulin sensitivity confirmed in the Maastricht Study
- aSAT immune cell populations not related to insulin sensitivity
- aSAT gene expression of interleukin 6 and CD14 positively associated with muscle, but not liver, insulin sensitivity
Observational data: associations, not effects.
Original publication
Circulating and adipose tissue immune cells in tissue‐specific insulin resistance in humans with overweight and obesity. Obesity (Silver Spring). Published 30 March 2023. doi:10.
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