Mortality Not Increased in Patients With Nonfunctional Adrenal Adenomas: A Matched Cohort Study
Authors' conclusion
NFAA does not seem to pose a clinically relevant risk for increased mortality in patients with adrenal incidentalomas while patients with MACS, and especially younger patients and those with cortisolDST ≥83 nmol/L, have significantly increased mortality risk compared with matched controls.
Study context
- Population
- Patients referred to 2 endocrine centres in southern Sweden for adrenal incidentaloma, 2005–20151,154 patients · 3462 controls
- Exposure
- Patients with adrenal incidentaloma by post-DST cortisol level vs matched controls
- Controlsn = 3,462reference
- Outcome
- All-cause mortality
- Follow-up
- Median 6.6 years
Methodological detailsmatched cohort, controls matched 3:1 for sex, age and residency, 2 endocrine centres, Outcome data from the Cause of Death Register
- Matched cohort
- Controls matched 3:1 for sex, age and residency
- 2 endocrine centres
- Outcome data from the Cause of Death Register
Main finding
As reported in the abstract
Each group vs controlsHazard ratio (CI)
NFAA
1.13(0.87–1.46)
cortisolDST 83-137
1.99(1.38–2.88)
cortisolDST ≥138
4.09(2.41–6.93)
- Deaths: patients
- 210
- Deaths: controls
- 505
Observational data: associations, not effects.
Further findings
| Outcome | HR (CI) | |
|---|---|---|
| All-cause mortality, patients <65 yearscortisolDST 50-82vs ControlsPatients younger than 65 years | 2.33 (1.30–4.17) | |
| 0.20.5125Hazard ratio (log scale) |
Original publication
Mortality Not Increased in Patients With Nonfunctional Adrenal Adenomas: A Matched Cohort Study. J Clin Endocrinol Metab. Published 17 February 2023. doi:10.
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