Cushing's syndrome in the elderly: data from the European Registry on Cushing's syndrome
Authors' conclusion
Older CS patients lack several typical symptoms of hypercortisolism, present with more comorbidities regardless of sex, and are more often conservatively treated.
Study context
- Population
- Patients with Cushing's Syndrome (CS) in the European Registry on Cushing's Syndrome (ERCUSYN): 1234 (69%) PIT-CS, 450 (25%) ADR-CS, 107 (6%) Ectopic Source (ECT-CS)
- Participants
- 1,791 patients
- Exposure
- Older vs younger patients with CS
- Oldern = 175
- Youngern = 1,616reference
- Outcome
- Clinical characteristics by age
Methodological detailsregistry-based, multicentre
- Registry-based
- Multicentre
Main finding
As reported in the abstract
- Older: lower prevalence of skin alterations, depression, hair loss, hirsutism and reduced libido; higher prevalence of muscle weakness, diabetes, hypertension, CVD, VTE and bone fractures, regardless of sex
- P < .01 for all comparisons
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Urinary free cortisol supporting CS diagnosisLess frequent in older | P < 0.05 |
| Extrasellar macroadenoma, PIT-CSMore common in older | P < 0.01 |
| Remission after transsphenoidal surgeryLower in older | P < 0.05 |
First-line treatment, PIT-CS
- Older more often received cortisol-lowering medications and radiotherapy; surgery preferred in younger
- P < 0.01 for all comparisons
Original publication
Cushing's syndrome in the elderly: data from the European Registry on Cushing's syndrome. Eur J Endocrinol. Published 7 February 2023. doi:10.
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