Infants with Congenital Adrenal Hyperplasia Exhibit Thalamic Discrepancies in Early Brain Structure
Main finding · Thalamic volume (adjusted for PCA and sex)Result — go to the resultβ −609Authors' conclusion
Infants with CAH exhibit smaller thalamic regions from early life, suggesting a prenatal influence on brain development in CAH. Thalamic emergence at 8-14 weeks makes the region particularly vulnerable to changes in the intrauterine environment, with potential implications for later maturing brain regions. These changes may take time to manifest, meriting longitudinal study through adolescence in CAH.
Study context
- Population
- Infants with classical congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency and healthy control infants
- Participants
- 16 vs 14
- Exposure
- Infants with classical CAH vs healthy control infants
- CAHn = 16
- Controlsn = 14reference
- Outcome
- Regional brain volumes on MRI, adjusted for post-conceptional age (PCA) and sex
Methodological details3-Tesla MRI, age-matched controls
- 3-Tesla MRI
- Age-matched controls
Main finding
Thalamic volume (adjusted for PCA and sex)
β
−609
P = 0.02
By group
As reported in the abstract
Observational data: associations, not effects.
Further findings
Temporal lobe volume (further adjusted for TBV) · larger with CAH
β 1,202 · P = 0.03
Brain regions most differentiating CAH vs controls (relaimpo analysis)
- Thalamus
- 22%
- Parietal lobe
- 10%
Original publication
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