High prevalence of venous thrombotic events in Cushing's syndrome: data from European Registry on Cushing's syndrome (ERCUSYN) and details in relation to surgery
Authors' conclusion
Patients with CS have an elevated risk of developing VTE for an extended period of time. From ERCUSYN cohort patients have higher risk for VTE if they need multiple surgeries to treat CS, are males and have high UFC values at the diagnosis of CS. Since there is no agreement on thromboprohpylaxis, a protocol for VTE prevention that is widely adopted appears to be necessary for patients with CS.
Study context
- Population
- Patients with Cushing's syndrome (CS) in the European Registry on Cushing's syndrome (ERCUSYN); data extraction February 7, 202295 venous thromboembolism (VTEs) reported
- Participants
- 2,174 patients
- Exposure
- CS patients with VTE vs without VTE
- Outcome
- Prevalence of VTE
Methodological detailsobservational, registry-based (ERCUSYN)
- Observational
- Registry-based (ERCUSYN)
Main finding
As reported in the abstract
VTE events by CS aetiology
- VTEs reported in database
- 95
- Pituitary-dependent CS
- 70 (74%)
- Adrenal-dependent CS
- 12 (12.5%)
- Ectopic CS
- 10 (10.5%)
- CS due to other causes
- 3 (3%)
Observational data: associations, not effects.
Further findings
Predictors of VTE
- Sex, 24-h urinary free cortisol (UFC) at diagnosis and number of operations remained statistically significant predictors of VTE
Timing of VTE relative to surgery (patients with ≥1 surgery)
- VTE before surgery
- 12 (13%)
- VTE after surgery
- 80 (87%)
- VTE within 6 months of operation
- 36; 45%
Thromboprophylaxis practice
- Over half of centres reporting VTE did not routinely anticoagulate CS patients; anticoagulation schemes varied widely
Original publication
High prevalence of venous thrombotic events in Cushing's syndrome: data from ERCUSYN and details in relation to surgery. Eur J Endocrinol. Published 26 December 2023. doi:10.
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