Adrenal disease

Delphi panel consensus on recommendations for thromboprophylaxis of venous thromboembolism in endogenous Cushing's syndrome: a position statement

Eur J EndocrinolPublished Delphi consensus position statement

An erratum to this article was published (Eur J Endocrinol, 30 May 2025 ↗)

Methodological details4 rounds of voting, 18 international experts from 11 countries, consensus ≥75% agreement, Consensus defined as ≥75% agreement
  • 4 rounds of voting
  • 18 international experts from 11 countries
  • Consensus ≥75% agreement
  • Consensus defined as ≥75% agreement

Recommendations

As issued by the authors

  1. Thromboprophylaxis should be considered at Cushing's syndrome (CS) diagnosis and continued for 3 months after biochemical remission, provided there are no obvious contraindications

  2. Standard weight-based prophylactic dose of low molecular-weight heparin is the preferred agent for thromboprophylaxis in CS

  3. Perioperatively and around inferior petrosal sinus sampling, thromboprophylaxis should be reconsidered if not already initiated at diagnosis

  4. For venous thromboembolism (VTE) treatment, extended thromboprophylaxis is advised, continuing for 3 months after Cushing is resolved

Original publication

Delphi panel consensus on recommendations for thromboprophylaxis of venous thromboembolism in endogenous Cushing's syndrome: a position statement. Eur J Endocrinol. Published 20 February 2025. doi:10.1093/ejendo/lvaf017

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