COVID‐19‐related adrenal haemorrhage: Multicentre UK experience and systematic review of the literature
Authors' conclusion
Adrenal haemorrhage with consequential adrenal insufficiency can be a complication of COVID-19 infection and vaccination. Adrenal function assessment is mandatory to avoid the potentially fatal consequences of unrecognized adrenal insufficiency.
Study context
- Population
- UK patients with COVID-19-related adrenal haemorrhage (AH), 8 UK centres11 survey, 7 from review
- Participants
- 18 patients
- Comparison
- Infection-related AH vs Vaccine-related AH
- Infection-related AHn = 7
- Vaccine-related AHn = 11
- Outcome
- Characteristics of COVID-19-related AH
Methodological detailssurvey of Society for Endocrinology (SfE) clinical membership, standardized data collection tool, descriptive, Eight UK centres responded to the survey with at least one case
- Survey of SfE clinical membership
- Standardized data collection tool
- Descriptive
- Eight UK centres responded to the survey with at least one case
Pooled result
As reported in the abstract
- Infection-related AH: bilateral
- 4
- Infection-related AH: males
- 4
- Infection-related AH: median age (range 26-70) years
- 53
- Infection-related AH: median time from positive COVID-19 test to AH detection (range 1-30) days
- 8
- Vaccine-related AH: bilateral
- 8
- Vaccine-related AH: males
- 3
- Vaccine-related AH: median age (range 23-78) years
- 47
- Vaccine-related AH: median time from vaccination to AH (range 2-27) days
- 9
- Vaccine-related AH after first vaccine dose
- 9/11
- Acute abdominal pain as presentation, AH of any cause
- 72%
- Required glucocorticoid replacement: patients with bilateral AH
- 12 (all)
- Required glucocorticoid replacement: patients with unilateral AH
- 1
Further pooled results
Systematic literature review: COVID-19-related AH cases
- Cases identified
- 25
- Bilateral
- 19
- Infection-related
- 13
- Vaccine-related
- 12
Original publication
COVID‐19‐related adrenal haemorrhage: Multicentre UK experience and systematic review of the literature. Clin Endocrinol (Oxf). Published 5 February 2023. doi:10.
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