Relationship Between Dexamethasone Suppression Test Cortisol Level >0.9 μg/dL and Depression and Quality of Life in Adrenal Incidentalomas: A Single Center Observational Case-Control Study
Authors' conclusion
MACS and patients with NFAI had similar QoL and depression scores according to the 1.8 μg/dL and above, whereas, had lower QoL and higher depression scores according to the 0.9 μg/dL.
Study context
- Population
- Patients with AI (nonfunctional adrenal incidentaloma (NFAI) or mild autonomic cortisol secretion (MACS)) and healthy controls, single centre
- Comparison
- AI with dexamethasone suppression test (DST) cortisol >0.9 μg/dL vs ≤0.9 μg/dL; MACS vs NFAI vs healthy controls
- NFAIn = 42
- MACSn = 53
- Healthy controls (HCs)n = 42reference
- Outcome
- BDI-II and QoL scores in AI by DST cortisol threshold >0.9 μg/dL
Methodological detailssingle-centre, observational
- Single-centre
- Observational
Main finding
As reported in the abstract
- Beck Depression Inventory-II (BDI-II) scores higher in AI >0.9 μg/dL than in AI ≤0.9 μg/dL and HCs
- AI >0.9 μg/dL vs AI ≤0.9 μg/dL: P = 0.003
Observational data: associations, not effects.
Further findings
Quality of life (QoL) and BDI-II scores, MACS vs NFAI
- No difference in QoL and BDI-II scores between MACS and NFAI
QoL and BDI-II scores, MACS and NFAI vs HCs
- BDI-II score higher and QoL lower in MACS and NFAI vs HCs
QoL and BDI-II scores, MACS vs NFAI at DST cortisol threshold 5.0 μg/dL
- Difference in QoL and BDI-II scores between MACS and NFAI remained insignificant at the higher threshold (5.0 μg/dL)
DST as independent factor for frequency of depression
- DST independent factor affecting frequency of depression, OR
- 1.39, P = .037
Original publication
Relationship Between Dexamethasone Suppression Test Cortisol Level >0.9 μg/dL and Depression and Quality of Life in Adrenal Incidentalomas: A Single Center Observational Case-Control Study. Endocr Pract. Published 8 May 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →