Microvascular Disease, Cardiovascular Health, and Risk of Coronary Heart Disease in Type 2 Diabetes: A UK Biobank Study
Main finding · Incident CHDResult — go to the resultHazard ratio 4.58 95% CI 3.58–5.86Authors' conclusion
Coexistence of multiple MVDs was associated with a substantially higher risk of CHD among individuals with T2DM. Such association may be amplified by unfavorable CVHMs.
Study context
- Population
- Participants with T2D from the UK Biobank with CVHM data, free of coronary heart disease (CHD) at recruitment3,252 incident CHD
- Participants
- 19,664 participants
- Exposure
- Number of microvascular disease (MVD) and CVHM status vs MVD-free with ideal cardiovascular health metrics (CVHMs)
- Outcome
- Incident coronary heart disease (CHD)
- Follow-up
- Median 12.3 years
Methodological detailsUK Biobank, multivariable Cox regression
- UK Biobank
- Multivariable Cox regression
Main finding
Incident CHD
Hazard ratio
4.58
95% CI 3.58–5.86
≥ 2 MVD, poor CVHMsvs MVD-free, ideal CVHMs
HR 4.58 (95% CI 3.58–5.86)
As reported in the abstract
- Risk of CHD with 1 MVD (increase, after multivariable adjustment)
- 27%
- Risk of CHD with ≥ 2 MVD (increase, after multivariable adjustment)
- 87%
Observational data: associations, not effects.
Original publication
Microvascular Disease, Cardiovascular Health, and Risk of Coronary Heart Disease in Type 2 Diabetes: A UK Biobank Study. J Clin Endocrinol Metab. Published 27 February 2024. doi:10.
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