Gestational diabetes & diabetes in pregnancy
Metagenomic characterization of the maternal prenatal gastrointestinal microbiome by pregravid BMI
Authors' conclusion
Our analysis suggests that there are differences in microbial composition and function between BMI groups. Future research should consider how these changes contribute to specific clinical outcomes during pregnancy.
Study context
- Population
- Pregnant women; maternal prenatal gastrointestinal microbiome by pregravid BMI
- Participants
- 105 biospecimens
- Exposure
- Pregravid BMI groups: obesity or overweight vs normal weight
- Outcome
- Gastrointestinal microbiome composition and function
Methodological detailsshotgun metagenomics
- Shotgun metagenomics
Main finding
As reported in the abstract
- Enrichment in Firmicutes across all pregravid BMI groups
- Obesity or overweight: enrichment in Bifidobacterium bifidum and B. adolescentis
- BMI > 25 kg/m²: higher abundance of microbiota supporting biotin synthesis and regulating lower GI epithelial cells
- Obesity or overweight vs Normal weight: P = 0.02
Observational data: associations, not effects.
Original publication
Metagenomic characterization of the maternal prenatal gastrointestinal microbiome by pregravid BMI. Obesity (Silver Spring). Published 23 December 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →