Metabolic and physiological responses to graded exercise testing in individuals with type 1 diabetes using insulin pump therapy
Authors' conclusion
In adults with long-standing type 1 diabetes using insulin pump therapy, circulating glucose remains stable during a graded incremental cycle test to volitional exhaustion. Glycaemic indicators are inversely associated with aerobic rate, oxygen economy and mechanical output across the exercise intensity spectrum. An appreciation of these nexuses may help guide appropriate decision making for optimal exercise management strategies.
Study context
- Population
- Adults with T1D using insulin pumps; 30 females; HbA1c 59.5 ± 0.5 mmol/mol (7.6 ± 1.0%); age 49.7 ± 13.0 years; diabetes duration 31.2 ± 13.5 years; V̇O2peak 29.5 ± 8.0 ml/min/kg
- Participants
- 45 adults4 pooled trials
- Outcome
- Glycaemic dynamics and physiological responses during graded exercise testing (GXT)
Methodological detailsidentical GXT protocols, age- and gender-adjusted general linear modelling
- Identical GXT protocols
- Age- and gender-adjusted general linear modelling
Pooled result
As reported in the abstract
- Plasma glucose at rest (remained similar throughout exercise, p = .419)
- 8.8 ± 2.3 mmol/L
- Overall change in plasma glucose during GXT
- +0.3 ± 1.1 mmol/L
- Change in V̇O2peak per 1% increment in HbA1c (p < .001)
- decrease of 3.8 ml/min/kg
- Change in powerpeak per 1% increment in HbA1c (p < .001)
- decrease of 0.33 W/kg
- Change in O2 pulse per 1% increment in HbA1c (p = .023)
- −1.2 ml/beat
Original publication
Metabolic and physiological responses to graded exercise testing in individuals with type 1 diabetes using insulin pump therapy. Diabetes Obes Metab. Published 3 January 2023. doi:10.
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