Comparison of Insulin Glargine 300 U/mL and Insulin Degludec 100 U/mL Around Spontaneous Exercise Sessions in Adults with Type 1 Diabetes: A Randomized Cross-Over Trial (ULTRAFLEXI-1 Study)
Authors' conclusion
TBR<70 within the first 24 h after spontaneous exercise sessions was significantly lower when receiving IGlar U300 compared to IDeg U100 when a regular basal dose was administered.
Study context
- Population
- Adults with T1D performing six spontaneous 60 min moderate-intensity evening cycle ergometer exercise sessions per 2-week period; mean age 41.4 ± 11.9 years, HbA1c 7.5% ± 0.8%14 males
- Participants
- 25 adults
- Comparison
- IGlar U300 vs IDeg U100 at 100% and 75% of regular dose on exercise days
- Primary endpoint
- TBR<70 mg/dL (3.9 mmol/L) during the 24 h postexercise periods, analysed in hierarchical order by repeated measures linear mixed model
- Follow-up
- 24 h postexercise
Methodological detailssingle-centre, four-period, cross-over
- Single-centre
- Four-period
- Cross-over
Primary result
As reported in the abstract
TBR<70
IGlar U300 (100%) vs IDeg U100 (100%): P = 0.023 · IGlar U300 (75%) vs IDeg U100 (75%): P = 0.720
Further findings
- Time in range 70-180 highest with IDeg U100 (100%)
Original publication
Comparison of Insulin Glargine 300 U/mL and Insulin Degludec 100 U/mL Around Spontaneous Exercise Sessions in Adults with Type 1 Diabetes: A Randomized Cross-Over Trial (ULTRAFLEXI-1 Study). Diabetes Technol Ther. Published 2 January 2023. doi:10.
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