Mediation of genetic susceptibility to obesity through eating behaviours in children
Authors' conclusion
Our results support the view that appetite is key to translating genetic susceptibility into changes in body weight.
Study context
- Population
- Children from a birth cohort; eating behaviours assessed 5 times at ages 2–6 years, height and weight measured 6 times at ages 6–13 yearsbirth cohort
- Participants
- 692 children
- Exposure
- Two body mass index (BMI) polygenic scores (child- and adult-based) predicting BMI z-scores, mediated by over-eating and fussy eating
- Outcome
- Contributions of the PGSs to BMI z-scores mediated by over-eating and fussy eating
- Follow-up
- Ages 6 to 13 years
Methodological detailslongitudinal growth curve mediation analysis
- Longitudinal growth curve mediation analysis
Main finding
As reported in the abstract
- PGSchild predicted BMI z-scores, β
- 0.26 (95% CI 0.19-0.33)
- PGSadult predicted BMI z-scores, β
- 0.34 (95% CI 0.27-0.41)
- Over-eating mediation of PGSchild at 6 years
- 18.0% (95% CI 3.1-32.9, p-value = 0.018)
- Over-eating mediation of PGSadult at 6 years
- 14.2% (95% CI 2.8-25.5, p-value = 0.014)
- Over-eating mediation of PGSchild at 13 years
- 11.4% (95% CI −0.4-23.1, p-value = 0.057)
- Over-eating mediation of PGSadult at 13 years
- 6.2% (95% CI 0.4-12.0, p-value = 0.037)
Observational data: associations, not effects.
Original publication
Mediation of genetic susceptibility to obesity through eating behaviours in children. Pediatr Obes. Published 10 October 2024. doi:10.
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