Maternal obesity and offspring cardiovascular remodelling — the effect of preconception and antenatal lifestyle interventions: a systematic review
Authors' conclusion
Although there is some evidence to suggest that lifestyle interventions in women with obesity may limit offspring cardiac remodelling, further high-quality longitudinal studies with larger sample sizes are required to confirm these observations and to determine whether these changes persist to adulthood. Child offspring cardiovascular health benefits of preconception and antenatal lifestyle interventions in women with obesity.
Study context
- Population
- Offspring of pregnant women with obesity in randomised trials of lifestyle interventions; children <2-months to 3–7-years-old8 studies from 5 RCTs
- Comparison
- Preconception or antenatal lifestyle interventions vs control in women with obesity
- Outcome
- Offspring cardiac remodelling and related cardiovascular parameters
Methodological detailsPRISMA-aligned, Risk of bias rated all studies 'fair' (some risk of bias), High loss-to-follow-up was a common limitation
- PRISMA-aligned
- Risk of bias rated all studies 'fair' (some risk of bias)
- High loss-to-follow-up was a common limitation
Pooled result
As reported in the abstract
Offspring cardiac remodelling
- Reduced cardiac remodelling, with reduced interventricular septal wall thickness, consistently reported
- Sample sizes n = 18-404
Further pooled results
Cardiac function and resting heart rate
- Some studies identified improved systolic and diastolic function and a reduced resting heart rate
Original publication
Maternal obesity and offspring cardiovascular remodelling — the effect of preconception and antenatal lifestyle interventions: a systematic review. Int J Obes (Lond). Published 19 June 2024. doi:10.
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