Obesity

The effect of methods used in the management of maternal obesity on pregnancy and birth outcomes: a systematic review with meta-analysis

Int J Obes (Lond)Published Systematic review and meta-analysis

Authors' conclusion

The study revealed that methods used in the treatment of maternal obesity may reduce some negative maternal and newborn outcomes, but it is more important to start pregnancy with an ideal weight.

Study context

Population
Pregnant women with obesity; 21 studies published 2013–2021
Participants
7,695 women21 studies
Comparison
Weight management interventions for maternal obesity vs control
Outcome
Pregnancy and birth outcomes
Methodological detailsPRISMA, ROB2 quality assessment, GRADE certainty of evidence
  • PRISMA
  • ROB2 quality assessment
  • GRADE certainty of evidence

Pooled result

As reported in the abstract

Weight management interventions significantly reduced weight gain during pregnancy
p < 0.001
Weight management interventions significantly reduced birth weight
p < 0.01
No effect on other adverse pregnancy outcomes in the synthesis
p > 0.05

Further pooled results

Subgroup: brochures

Lower birth weight
P < 0.01
Lower weight gained during pregnancy
P < 0.001

Subgroup: metformin

Significant drop in neonatal ICU admissions
P < 0.01

Subgroup: exercise

Lower gestational diabetes
P < 0.001
Lower weight gained during pregnancy
P < 0.001
Lower birth weight
P = 0.01
Lower large-for-gestational-age baby birth
P < 0.05

Subgroup: diet and exercise combined

Significantly reduced weight gained during pregnancy
P = 0.001

GRADE certainty of evidence

Critical outcomes with high certainty
15 of 15

Original publication

The effect of methods used in the management of maternal obesity on pregnancy and birth outcomes: a systematic review with meta-analysis. Int J Obes (Lond). Published 26 March 2025. doi:10.1038/s41366-025-01748-y

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