Gestational diabetes & diabetes in pregnancy
Maternal Diabetes and Cardiac Left Ventricular Structure and Function in the Infant: A Copenhagen Baby Heart Study
Authors' conclusion
Maternal preexisting diabetes and, to a lesser extent, GDM were associated with changes in infant LV structure and function.
Study context
- Population
- Infants with transthoracic echocardiography within 60 days of birth
- Participants
- 25,486 infants
- Exposure
- Maternal preexisting diabetes or gestational diabetes mellitus (GDM) vs unexposed
- Preexisting diabetesn = 198
- GDMn = 649
- Unexposedn = 24,639reference
- Outcome
- Infant LV structural and functional parameters
- Follow-up
- Within 60 days of birth
Methodological detailspopulation-based (Copenhagen Baby Heart Study), transthoracic echocardiography within 60 days of birth, linear regression, adjusted mean differences
- Population-based (Copenhagen Baby Heart Study)
- Transthoracic echocardiography within 60 days of birth
- Linear regression, adjusted mean differences
Main finding
As reported in the abstract
- Preexisting diabetes vs Unexposed · thicker with preexisting diabetes
- aMD, left ventricular (LV) posterior wall thickness 0.19 mm (95% CI 0.11–0.27)
- Between Preexisting diabetes and Unexposed · smaller with preexisting diabetes
- aMD, LV internal diameter in systole −0.27 mm (95% CI −0.45 to −0.18)
- Preexisting diabetes vs Unexposed · smaller with preexisting diabetes
- aMD, LV internal diameter in diastole −0.37 mm (95% CI −0.59 to −0.09)
- Preexisting diabetes vs Unexposed · reduced with preexisting diabetes
- aMD, stroke volume −0.36 mL (95% CI −0.61 to −0.11)
- Preexisting diabetes vs Unexposed · increased with preexisting diabetes
- aMD, heart rate 3.14 bpm (95% CI 1.10–6.18)
- Preexisting diabetes vs Unexposed · increased with preexisting diabetes
- aMD, mitral valve early peak velocity 2.17 cm/s (95% CI 0.31–4.04)
Observational data: associations, not effects.
Further findings
| Outcome | aMD, LV internal diameter in systole (mm) (95% CI) |
|---|---|
| LV structure and function, GDM vs unexposedSignificantly smaller with GDM | −0.13 (−0.22 to −0.03) |
LV structure and function, GDM vs unexposed
- Similar structural and functional changes as with preexisting diabetes, albeit with smaller nonsignificant adjusted mean differences (aMDs)
Third-trimester HbA1c
- Higher HbA1c associated with smaller LV internal diameters and stroke volumes in infants exposed to preexisting diabetes
- Higher HbA1c associated with lower heart rates in infants exposed to GDM
Original publication
Maternal Diabetes and Cardiac Left Ventricular Structure and Function in the Infant: A Copenhagen Baby Heart Study. Diabetes Care. Published 15 October 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →