Lipids & metabolic liver disease
Magnitude and time course of insulin resistance accumulation with the risk of cardiovascular disease: an 11-years cohort study
Main finding · Incident CVD by cumMETS-IRResult — go to the resultHazard ratio 1.77 95% CI 1.58–1.98Authors' conclusion
The risk of CVD increased with elevated cumMETS-IR and an increasing trend over time, emphasizing the importance of maintaining optimal METS-IR levels across life span.
Study context
- Population
- Participants without cardiovascular disease (CVD) who underwent three examinations during 2006–2010, Kailuan study3,184 incident CVD cases
- Participants
- 47,270 participants
- Exposure
- Higher vs lower cumulative METS-IR (cumulative metabolic score for IR (cumMETS-IR)), exposure duration, cumulative burden and slope of METS-IR
- Outcome
- Incident CVD
- Follow-up
- Median 10.99 years
Methodological detailsmultivariable-adjusted Cox regression
- Multivariable-adjusted Cox regression
Main finding
Incident CVD by cumMETS-IR
Hazard ratio
1.77
95% CI 1.58–1.98
Q4vs Q1
HR 1.77 (95% CI 1.58–1.98)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Incident CVD by exposure duration6 yearsvs 0 years | 1.60 (1.45–1.77) | |
| Incident CVD by cumulative burdenBurden ≥ 0vs Burden < 0 | 1.49 (1.37–1.61) | |
| 0.512Hazard ratio (log scale) |
Incident CVD by positive slope of METS-IR
| HR (95% CI) | ||
|---|---|---|
| Positive slope14% higher risk | 1.14 (1.07–1.22) | |
| 0.512Hazard ratio (log scale) |
Incident CVD with cumMETS-IR ≥ median (142.78) and slope ≥ 0
| HR (95% CI) | ||
|---|---|---|
| cumMETS-IR ≥ median and slope ≥ 0Highest risk of CVD | 1.38 (1.25–1.53) | |
| 0.512Hazard ratio (log scale) |
Original publication
Magnitude and time course of insulin resistance accumulation with the risk of cardiovascular disease: an 11-years cohort study. Cardiovasc Diabetol. Published 13 December 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →