Lower free triiodothyronine levels are associated with higher all-cause and cardiovascular mortality in people with diabetes-NHANES 2007–2012
Authors' conclusion
FT3 is an independent predictor of all-cause death, cardio-cerebrovascular and cardiovascular death in euthyroid subjects with diabetes.
Study context
- Population
- Euthyroid individuals with diabetes in NHANES, United States, 2007–2012
- Participants
- 1,208 individuals
- Exposure
- Higher vs lower free triiodothyronine (FT3) levels
- Outcome
- All-cause and cardiovascular mortality
Methodological detailsweighted Kaplan-Meier analysis, multivariate adjusted Cox proportional hazards models
- Weighted Kaplan-Meier analysis
- Multivariate adjusted Cox proportional hazards models
Main finding
As reported in the abstract
Mortality by FT3 level (multivariate adjusted Cox models)
All-cause mortality, higher FT3: HR
0.715 (0.567, 0.900) (95% CI)
Cardio-cerebrovascular mortality, higher FT3: HR
0.576 (0.408, 0.814) (95% CI)
Cardiovascular mortality, higher FT3: HR
0.629 (0.438, 0.904) (95% CI)
Observational data: associations, not effects.
Further findings
Survival probabilities across FT3, free thyroxine (FT4), FT3/FT4 ratio and thyroid-stimulating hormone (TSH) groups (weighted Kaplan-Meier (KM))
- Statistically significant differences in survival probabilities across FT3, FT4, FT3/FT4 ratio and TSH groups
- P < 0.05 or < 0.001
FT3–mortality association by age (nonlinear regression)
- Correlation more significant among individuals over the age of 60
Original publication
Lower free triiodothyronine levels are associated with higher all-cause and cardiovascular mortality in people with diabetes-NHANES 2007–2012. Diabetes Res Clin Pract. Published 28 June 2023. doi:10.
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