Increasing cardiovascular mortality in young adults with diabetes mellitus as a contributing cause in the United States
Authors' conclusion
Our study reveals a rising trend in CVD mortality in young adults with DM as a contributing cause. Males, non-Hispanic Black individuals, and individuals from rural regions had higher AAMR than their counterparts. This warrants the development of specific healthcare policies aimed at these at-risk populations.
Study context
- Population
- Young adults aged 15 to 44 years in the US, 1999–2019 (secondary analysis 2020–2022), with CVD as the main cause of death and diabetes mellitus (DM) as a contributing cause
- Participants
- 30,978 deaths
- Outcome
- AAMR per 100 000 for CVD deaths with comorbid DM as contributing cause; temporal trend as average annual percent change (AAPC)
- Follow-up
- 1999 to 2019
Methodological detailsCDC WONDER database, Joinpoint regression
- CDC WONDER database
- Joinpoint regression
Main finding
As reported in the abstract
Overall AAMR per 100 000 individuals
Age-adjusted mortality rates (AAMR) in 1999
1.08 per 100 000 individuals
AAMR in 2019
1.23 per 100 000 individuals
Average APC
0.75
95% CI 0.31–1.20
Observational data: associations, not effects.
Further findings
| Outcome | Values |
|---|---|
| AAMR by sex | Males 1.60 · Females 0.97 |
| AAMR by race/ethnicity (highest) | Non-Hispanic Black 2.99 · Non-Hispanic American Indian/Alaska Native 2.89 |
| AAMR by region | Rural 1.63 · Urban 1.23 |
% change in CVD deaths, 2019 vs 1999
- With comorbid DM
- +6.2%
- Without comorbid DM (decrease)
- 19.9%
Overall AAMR during COVID-19 pandemic period · 2019 to 2022
- AAMR in 2019
- 1.23
- AAMR in 2022
- 1.60
- Similar pattern across demographic subgroups
Original publication
Increasing cardiovascular mortality in young adults with diabetes mellitus as a contributing cause in the United States. Diabetes Obes Metab. Published 5 January 2026. doi:10.
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