Effect of Early Glycemic Control in Youth-Onset Type 2 Diabetes on Longer-Term Glycemic Control and β-Cell Function: Results From the TODAY Study
Authors' conclusion
Early tight glycemic control in the TODAY study was related to β-cell reserve and translated to better long-term glycemic control. However, tight early glycemic control on the randomized treatment in the TODAY study did not prevent deterioration of β-cell function.
Study context
- Population
- Adolescents with youth-onset T2D in the TODAY study; 64.8% female, baseline mean age 14 years, diabetes duration <2 yearslongitudinal data available
- Participants
- 656 adolescents
- Comparison
- Early glycemic control categories
- Primary endpoint
- Long-term β-cell function and glycemic control (HbA1c) by early glycemia category
- Follow-up
- Years 2–9
Methodological detailslongitudinal, Follow-up average 6.4 ± 3.2 years
- Longitudinal
- Follow-up average 6.4 ± 3.2 years
Primary result
As reported in the abstract
HbA1c change over time · years 2-9
Steeper HbA1c increase with tightest initial control (mean early HbA1c <5.7%)
+0.40%/year
Original publication
Effect of Early Glycemic Control in Youth-Onset Type 2 Diabetes on Longer-Term Glycemic Control and β-Cell Function: Results From the TODAY Study. Diabetes Care. Published 28 June 2023. doi:10.
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