Circulating MicroRNAs as Predictors of Beta Cell Function in Youth-onset Type 2 Diabetes: The TODAY Study
Authors' conclusion
The miRNA species associated with beta cell function are associated with alterations in cellular metabolism and apoptosis, suggesting that differences in baseline abundance may serve as circulating markers of beta cell dysfunction and provide potential mechanistic insights into the aggressive nature of youth-onset type 2 diabetes.
Study context
- Population
- Youth-onset T2D participants of the TODAY study17 microRNA (miRNAs) by PCR
- Participants
- 365 participants
- Primary endpoint
- TODAY primary outcome: HbA1c ≥ 8% for at least 6 months (treatment failure)
Methodological detailsintervention trial followed by an observational phase, Samples at baseline, 24, 60, 96, and 120 months
- Intervention trial followed by an observational phase
- Samples at baseline, 24, 60, 96, and 120 months
Primary result
As reported in the abstract
Baseline miRNA log2 fold-changes remaining significant predictors of C-peptide oral disposition index (oDI) decline ≥20% (P < .05)
3
Increased miRNA-155 associated with oDI decline, OR
1.2 (1.1-1.4) (95% CI)
Increased miRNA-130b associated with oDI decline, OR
1.3 (1.0-1.7) (95% CI)
Decreased miRNA-126 associated with oDI decline, OR
0.6 (.4-.8) (95% CI)
Further findings
Treatment failure · baseline
- Baseline miRNAs independently predicting treatment failure (backward selection); baseline hemoglobin A1c (HbA1c) higher in those with failure
- 4
miRNA-122 correlations
- Negative correlation with C-peptide oDI, baseline
- R = 0.22, P < .01
- Negative correlation with C-peptide oDI, 24 months
- R = 0.19, P < .01
- Positive correlation with proinsulin, baseline
- R = 0.26, P < 0.01
- Positive correlation with proinsulin, 24 months
- R = 0.26, P < .01
- Positive correlation with proinsulin, 60 months
- R = 0.18, P < .01
Original publication
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