Low-density lipoprotein cholesterol levels are associated with first-phase insulin release
Authors' conclusion
The present results suggest that LDL cholesterol is a positive modulator of insulin secretion. The deterioration in glycemic control observed during treatment with statins might thus be explained by an impairment in insulin secretion due to the cholesterol-lowering effect of statins.
Study context
- Population
- Adult first-degree relatives of patients with T2D
- Participants
- 356 relatives
- Outcome
- Association of low-density lipoprotein (LDL) levels with insulin sensitivity (euglycemic hyperinsulinemic clamp) and first-phase insulin secretion (IVGTT and OGTT)
Main finding
As reported in the abstract
- LDL-C not independently associated with insulin-stimulated glucose disposal
- LDL-C positively, independently associated with acute insulin response (AIR) during intravenous glucose tolerance test (IVGTT), after adjustment for potential confounders
- LDL-C positively, independently associated with OGTT-derived Stumvoll first-phase insulin secretion index, after adjustment for potential confounders
- β-cell function (disposition index: AIR × insulin-stimulated glucose disposal) significantly associated with LDL-C, even after further adjustment for confounders
Observational data: associations, not effects.
Original publication
Low-density lipoprotein cholesterol levels are associated with first-phase insulin release. Diabetes Res Clin Pract. Published 20 March 2023. doi:10.
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