Longitudinal changes in BMD in adults with cystic fibrosis
Authors' conclusion
Individuals with CF experience bone loss at an age when it is not anticipated, thereby entering early adulthood, where further bone loss is inevitable especially with the decrease in estrogen during menopause, with suboptimal BMD.
Study context
- Population
- Adults with cystic fibrosis aged 25–48 yr with ≥1 DXA scan, followed January 2000–December 2021; scans posttransplantation or after bisphosphonates or CFTR modulator therapy excluded
- Participants
- 500 adults1,502 DXA scans
- Outcome
- BMD (g/cm²) at the LS and FN; average annual change
Methodological detailslinear mixed-effects model with random intercept and random slope
- Linear mixed-effects model with random intercept and random slope
Main finding
As reported in the abstract
Annual change in BMD
Annual decline in BMD at FN
−0.008 gm/cm²/yr
95% CI −0.009 to −0.007
Annual decline in BMD at LS
−0.006 gm/cm²/yr
95% CI −0.007 to −0.004
Observational data: associations, not effects.
Further findings
BMD decline by age 48 yr relative to BMD at age 25
- Decline at FN
- 18.8%
- Decline at LS
- 11%
Rate of BMD decline by pancreatic status
- Pancreatic insufficient subjects had a faster rate of decline in BMD vs pancreatic sufficient subjects
Annual BMD decline adjusted for markers of disease severity
- Annual rate of decline remained significant after adjustment
Original publication
Longitudinal changes in BMD in adults with cystic fibrosis. J Bone Miner Res. Published 2 September 2024. doi:10.
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