Osteoporosis treatment prevents hip fracture similarly in both sexes: the FOCUS observational study
Authors' conclusion
we conclude that osteoporosis treatment prevents hip fracture similarly in both sexes.
Study context
- Population
- Patients aged ≥65 with hip-containing CT scan (2005–2018) in a large integrated healthcare system, testing positive for osteoporosis (DXA-equivalent hip BMD T-score ≤ −2.5); first hip fracture cases and sex-matched equal number of random patients2,211 women · 728 men
- Comparison
- Osteoporosis treatment vs no treatment, in men vs women
- Outcome
- Sex-specific OR of hip fracture for treated vs not-treated
- Follow-up
- two-year follow-up
Methodological detailsobservational, sex-matched, CT-based BMD (VirtuOst)
- Observational
- Sex-matched
- CT-based BMD (VirtuOst)
Main finding
As reported in the abstract
Hip fracture, treated vs not-treated, by sex
Estimate (95% CI)
Treatedvs Not-treatedwomen
OR (women) 0.26(0.21–0.33)
Treatedvs Not-treatedmen
OR (men) 0.21(0.13–0.34)
- Men vs Women · no significant sex effect
- ratio of ORs (men:women) 0.81 (95% CI 0.47–1.37)
Observational data: associations, not effects.
Further findings
Treatment status and hip fractures by sex · two-year follow-up
- Women treated (primarily alendronate)
- 33.9% (750/2,211)
- Men treated (primarily alendronate)
- 24.0% (175/728)
- Women not-treated
- 51.3%
- Men not-treated
- 66.3%
- Women with first hip fracture
- 721
- Men with first hip fracture
- 269
Sensitivity and stratified analyses · five-year follow-up
- Various sensitivity and stratified analyses confirmed these trends, including at five-year follow-up
Original publication
Osteoporosis treatment prevents hip fracture similarly in both sexes: the FOCUS observational study. J Bone Miner Res. Published 11 June 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →