Improved Clinical Outcomes Associated With Hungry Bone Syndrome Following Parathyroidectomy in Dialysis Patients
Authors' conclusion
HBS was associated with more pronounced improvements in blood pressure, anemia, and nutritional parameters. The presence of HBS could indicate greater achievement in controlling hyperparathyroidism following parathyroidectomy.
Study context
- Population
- Dialysis patients with severe secondary hyperparathyroidism who underwent parathyroidectomy, 2012–2022322 cases
- Participants
- 314 patients
- Exposure
- Hungry bone syndrome (HBS) vs no HBS after parathyroidectomy
- HBSn = 207
- Outcome
- HBS incidence
Methodological detailssingle-center
- Single-center
Main finding
As reported in the abstract
HBS occurred
207 cases
64%
Observational data: associations, not effects.
Further findings
Clinical outcomes over 3-12 months of follow-up
- Greater reduction in blood pressure and more significant increases in hemoglobin, total lymphocyte count and serum creatinine with HBS
- More substantial decrease in proportions with hemoglobin <11 g/dL and serum creatinine/body surface area <380 μmol/L/m² with HBS
- Greater parathyroid hormone (PTH) decline from baseline with HBS; similar proportions achieved target PTH
- Serum calcium substantially lower with HBS throughout follow-up; serum phosphate and PTH comparable
Surgical procedures
Cases
- Total parathyroidectomy
- 28 (8.7%)
- Total parathyroidectomy with implantation
- 98 (30.4%)
- Subtotal parathyroidectomy
- 196 (60.9%)
Safety
- Longer hospital stays with HBS but no increase in other adverse events
Original publication
Improved Clinical Outcomes Associated With Hungry Bone Syndrome Following Parathyroidectomy in Dialysis Patients. Endocr Pract. Published 29 August 2024. doi:10.
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