Long-term prognostic value of myocardial work analysis across obesity stages: insights from a community-based study
Authors' conclusion
Myocardial work metrics were significant predictors of long-term outcomes in low-risk individuals with different stages of obesity. Our findings highlight that conventional echocardiographic metrics may underestimate cardiovascular risk in patients with overweight and obesity.
Study context
- Population
- Low-risk volunteers from the Budakalász population-based screening program, stratified by BMI; all underwent 2D echocardiography (LVEF, global longitudinal strain (GLS), GWI, global wasted work (GWW), GWE)
- Participants
- 1,330 volunteers
- Exposure
- Myocardial work indices across BMI categories
- Outcome
- All-cause mortality
- Follow-up
- Median 11 years
Methodological detailscommunity-based, population-based screening program
- Community-based
- Population-based screening program
Main finding
As reported in the abstract
median follow-up 11 years
Estimate (95% CI)P value
Overweight
HR (GWE) 0.917(0.874–0.963)
P < 0.00Overweight
HR (GWW) 1.341(1.121–1.604)
P = 0.001Obesity
HR (GWI) 0.929(0.875–0.986)
P = 0.015- Deaths during follow-up
- 138 (10.4%)
Observational data: associations, not effects.
Original publication
Long-term prognostic value of myocardial work analysis across obesity stages: insights from a community-based study. Int J Obes (Lond). Published 6 August 2025. doi:10.
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