Regional and systemic adipose mass and peripheral conduit artery function
Authors' conclusion
In adults with obesity and insulin resistance, higher visceral adiposity, but not systemic and regional fat mass, is independently associated with impaired vascular function. These findings suggest that visceral fat distribution may have detrimental effects on vascular health, distinct from its impact on insulin sensitivity.
Study context
- Population
- Pre-diabetic adults aged 18–65 with obesity (body mass index (BMI) ≥ 30 kg/m²), 69 % female
- Participants
- 93 adults
- Outcome
- Correlation of brachial artery FMD with body composition (DEXA) and insulin resistance (HOMA-IR, Matsuda Index)
Main finding
As reported in the abstract
- FMD vs BMI: r = 0.12, p = 0.24
- FMD vs total body fat (kg): r = −0.12, p = 0.31
- FMD vs arm fat (kg): r = 0.00, p = 0.99
- FMD vs Waist:Hip ratio (inverse): r = −0.24, p = 0.03
- FMD vs total body lean mass (inverse): r = −0.32, p = 0.005
- FMD vs arm lean mass (inverse): r = −0.25, p < 0.03
Observational data: associations, not effects.
Further findings
Correlation of FMD with Waist:Hip ratio after adjustment
- Adjusted for HOMA-IR: r = - 0.31, P = 0.01
- Adjusted for Matsuda Index: r = - 0.31, P < 0.01
- Adjusted for sex: r = −0.35, p = 0.006
Original publication
Regional and systemic adipose mass and peripheral conduit artery function. Diabetes Res Clin Pract. Published 6 August 2025. doi:10.
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