Long-term Exposure to Ambient PM2.5 and Its Components Associated With Diabetes: Evidence From a Large Population-Based Cohort From China
Authors' conclusion
Long-term exposure to BC, nitrate, ammonium, OM, and SOIL is positively associated with diabetes. Moreover, OM might be the most responsible for the relationship between PM2.5 and diabetes. This study adds to the evidence of a PM2.5-diabetes association and suggests controlling sources of OM to curb the burden of PM2.5-related diabetes.
Study context
- Population
- Adults with no history of diabetes, large-scale epidemiologic survey in Southwest China, 2018–2019
- Participants
- 69,210 adults
- Exposure
- Per-SD increase in long-term exposure to PM2.5 and its components
- Outcome
- Diabetes (FPG ≥7.0 mmol/L (126 mg/dL) or HbA1c ≥48 mmol/mol (6.5%))
Methodological detailspopulation-based, large-scale epidemiologic survey, Annual average concentrations of PM2.5 and components estimated by satellite remote sensing and chemical transport modeling
- Population-based
- Large-scale epidemiologic survey
- Annual average concentrations of PM2.5 and components estimated by satellite remote sensing and chemical transport modeling
Main finding
As reported in the abstract
Diabetes per-SD increase in 3-year average concentrations
- PM2.5: OR
- 1.08 (1.01-1.15) (95% CI)
- Black carbon (BC): OR
- 1.07 (1.01-1.15) (95% CI)
- Ammonium: OR
- 1.07 (1.00-1.14) (95% CI)
- Nitrate: OR
- 1.08 (1.01-1.16) (95% CI)
- Organic matter (OM): OR
- 1.09 (1.02-1.16) (95% CI)
- Soil particles (SOIL): OR
- 1.09 (1.02-1.17) (95% CI)
Observational data: associations, not effects.
Further findings
Joint exposure to PM2.5 and its components and diabetes
- Joint exposure: OR
- 1.04 (1.01-1.07) (95% CI)
- Estimated weight of OM was the largest among PM2.5 and its components
- Weighted quantile sum method
Diabetes by age
- Associations were stronger in those ≥65 years
Original publication
Long-term Exposure to Ambient PM2.5 and Its Components Associated With Diabetes: Evidence From a Large Population-Based Cohort From China. Diabetes Care. Published 16 November 2022. doi:10.
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