Life Course Associations Between Ambient Fine Particulate Matter and the Prevalence of Prediabetes and Diabetes: A Longitudinal Cohort Study in Taiwan and Hong Kong
Authors' conclusion
Our findings suggest a link between PM2.5 exposure during each life stage and the prevalence of prediabetes/diabetes in adulthood, with the health impacts of exposure during adulthood being slightly greater. This study underscores the need for life course air pollution control strategies to mitigate the substantial disease burden of diabetes.
Study context
- Population
- Individuals from two open cohorts in Taiwan and Hong Kong, 2000–2018; PM2.5 assessed by satellite-based model (2-year average, 1 km² resolution)
- Participants
- 4,551 individuals19,593 medical visits
- Exposure
- Per 10 μg/m³ increase in ambient PM2.5 exposure
- Outcome
- Prevalence of prediabetes/diabetes
Methodological detailstwo open cohorts, logistic mixed-effects models, life course models
- Two open cohorts
- Logistic mixed-effects models
- Life course models
Main finding
As reported in the abstract
Prediabetes/diabetes, longitudinal association per 10 μg/m³ increase in PM2.5 · average follow-up 9.93 years
OR per 10 μg/m³ increase in PM2.5
1.32
95% CI 1.13, 1.54
Individuals with prediabetes/diabetes observed
1,660
Observational data: associations, not effects.
Further findings
Adulthood prediabetes/diabetes by life stage of exposure, per 10 μg/m³ increase in PM2.5
- Increase in odds, exposure during school age
- 15%
- Increase in odds, exposure during adolescence
- 18%
- Increase in odds, exposure during adulthood
- 29%
Original publication
Life Course Associations Between Ambient Fine Particulate Matter and the Prevalence of Prediabetes and Diabetes: A Longitudinal Cohort Study in Taiwan and Hong Kong. Diabetes Care. Published 12 November 2024. doi:10.
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