Sleep Duration and Risks of Incident Cardiovascular Disease and Mortality Among People With Type 2 Diabetes
Authors' conclusion
Short and long sleep durations were independently associated with increased risks of CVD onset and death among people with type 2 diabetes.
Study context
- Population
- Participants with T2D in the UK Biobank, free of cardiovascular disease (CVD) and cancer at baseline; sleep duration by baseline questionnaire
- Participants
- 18,876 participants
- Exposure
- Sleep duration ≤5 h/day and ≥10 h/day vs 7 h/day
- Outcome
- Incident atherosclerotic cardiovascular disease (ASCVD) and CVD mortality
- Follow-up
- Average 11.0-12.0 years
Main finding
As reported in the abstract
Incident ASCVD (2,570 cases)
Each group vs 7 h/dayMultivariable-adjusted HR (95% CI)
≤5 h/day
1.26(1.08–1.48)
≥10 h/day
1.41(1.16–1.70)
Observational data: associations, not effects.
Further findings
| Outcome | Multivariable-adjusted HR (95% CI) | |
|---|---|---|
| CVD mortality (598 deaths)≤5 h/dayvs 7 h/day | 1.42 (1.02–1.97) | |
| CVD mortality (598 deaths)≥10 h/dayvs 7 h/day | 1.85 (1.30–2.64) | |
| Coronary artery disease≤5 h/dayvs 7 h/day | 1.22 (0.99–1.50) | |
| Coronary artery disease≥10 h/dayvs 7 h/day | 1.16 (0.88–1.52) | |
| Ischemic stroke≤5 h/dayvs 7 h/day | 1.70 (1.23–2.35) | |
| Ischemic stroke≥10 h/dayvs 7 h/day | 2.08 (1.44–3.01) | |
| Peripheral artery disease≤5 h/dayvs 7 h/day | 1.02 (0.72–1.44) | |
| Peripheral artery disease≥10 h/dayvs 7 h/day | 1.45 (1.01–2.10) | |
| 0.20.5125Multivariable-adjusted HR (log scale) |
Sensitivity and joint analyses
- Similar results in most sensitivity analyses addressing reverse causation and in joint analyses of sleep duration and metabolic control or diabetes severity status
Original publication
Sleep Duration and Risks of Incident Cardiovascular Disease and Mortality Among People With Type 2 Diabetes. Diabetes Care. Published 16 November 2022. doi:10.
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