Long-Term Consequences of Cushing Syndrome: A Systematic Literature Review
Authors' conclusion
Although the limited patient numbers in many studies preclude definitive conclusions, most recent evidence supports the persistence of increased morbidity and mortality even after long-term remission.
Study context
- Population
- Patients with endogenous Cushing syndrome (CS); long-term consequences after disease remission79 papers included
- Outcome
- Persistence of comorbidities and mortality after CS remission
Methodological detailsPubMed and Embase search, papers published January 1, 2000, to December 31, 2022, 1907 potentially eligible records identified, 79 papers classified by main topic: cardiometabolic risk, thromboembolic disease, bone impairment, muscle damage, mood disturbances and QoL, cognitive impairment, mortality
- PubMed and Embase search
- Papers published January 1, 2000, to December 31, 2022
- 1907 potentially eligible records identified
- 79 papers classified by main topic: cardiometabolic risk, thromboembolic disease, bone impairment, muscle damage, mood disturbances and QoL, cognitive impairment, mortality
Main finding
As reported in the abstract
- Most recent evidence supports persistence of increased morbidity and mortality even after long-term remission
- Degree of normalization of comorbid conditions conceivably depends on individual factors and characteristics of the conditions
- Limited patient numbers in many studies preclude definitive conclusions
Original publication
Long-Term Consequences of Cushing Syndrome: A Systematic Literature Review. J Clin Endocrinol Metab. Published 3 August 2023. doi:10.
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