Leptin and adiposity measures from birth to later childhood: Findings from the Hyperglycemia and Adverse Pregnancy Outcomes Follow‐Up Study
Authors' conclusion
CB leptin is positively associated with neonatal and childhood adiposity and child leptin levels, independent of maternal BMI and maternal hyperglycemia. CB leptin may be a biomarker of future adiposity risk.
Study context
- Population
- Children from a prospective birth cohort with adiposity measured at birth and at mean age 11.5 years986 cord blood (CB), 931 childhood samples
- Outcome
- Associations of log-transformed CB leptin with childhood adiposity measures and childhood leptin
- Follow-up
- Mean age 11.5 years
Methodological detailsfollow-up of the Hyperglycemia and Adverse Pregnancy Outcomes Study
- Follow-up of the Hyperglycemia and Adverse Pregnancy Outcomes Study
Main finding
As reported in the abstract
Childhood adiposity per log CB leptin, adjusted for maternal BMI and glucose
- Body fat percentage, β
- 1.15% (CI 0.46-1.84)
- Body fat mass, β
- 0.69 kg (95% CI 0.16-1.23)
- Sum of skin-folds, β
- 1.77 mm (95% CI 0.31-3.24)
- Log child serum leptin, β
- 0.13 (95% CI 0.06-0.20)
- Overweight/obesity, OR
- 1.21 (95% CI 1.03-1.42)
- Obesity, OR
- 1.31 (95% CI 1.04-1.66)
- Body fat percentage >85th percentile, OR
- 1.38 (95% CI 1.12-1.73)
Observational data: associations, not effects.
Further findings
Neonatal adiposity · birth
- CB leptin positively associated with newborn adiposity measures, confirming previous reports
Original publication
Leptin and adiposity measures from birth to later childhood: Findings from the Hyperglycemia and Adverse Pregnancy Outcomes Follow‐Up Study. Pediatr Obes. Published 14 December 2023. doi:10.
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