Altered Glucagon and GLP-1 Responses to Oral Glucose in Children and Adolescents With Obesity and Insulin Resistance
Authors' conclusion
Children and adolescents with OIR have elevated fasting concentrations of glucagon and GLP-1, higher glucagon and lower GLP-1 responses during an OGTT compared to those with OIS and NW. In contrast, individuals with OIS have similar hormone responses to those with NW.
Study context
- Population
- Children and adolescents aged 7–17 years (34 boys) undergoing an OGTT34 boys
- Participants
- 80 children
- Exposure
- Obesity and insulin resistance (OIR) vs OIS vs normal weight (NW)
- OIRn = 22
- OISn = 22
- NWn = 36reference
- Outcome
- Fasting and stimulated glucagon, GLP-1 and GIP concentrations
Main finding
As reported in the abstract
Fasting and OGTT-stimulated glucagon, GLP-1 and GIP
- Fasting glucagon and GLP-1 higher in OIR
- No significant differences in fasting GIP
- OIR had higher glucagon total area under the curve (tAUC0-120) and lower GLP-1 incremental AUC (iAUC0-120)
- No significant differences in GIP iAUC0-120
Observational data: associations, not effects.
Further findings
Associations with insulin sensitivity/secretion indices
- Higher fasting glucagon associated with higher homeostatic model assessment of insulin resistance (HOMA-IR), lower Matsuda index, lower single point insulin sensitivity estimator (SPISE), higher insulinogenic index (IGI) and higher plasma alanine transaminase
- Higher fasting GLP-1 associated with higher HOMA-IR, lower Matsuda index and lower oral disposition index (ODI)
- Higher glucagon tAUC0-120 associated with lower SPISE and lower Matsuda index
- Lower GLP-1 iAUC0-120 associated with higher HOMA-IR, lower Matsuda index and lower ODI
Original publication
Altered Glucagon and GLP-1 Responses to Oral Glucose in Children and Adolescents With Obesity and Insulin Resistance. J Clin Endocrinol Metab. Published 13 December 2023. doi:10.
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