Left atrioventricular interaction and impaired left atrial phasic function in type 2 diabetes mellitus patients with or without anemia: a cardiac magnetic resonance study
Authors' conclusion
Both LA and LV function were severely impaired in T2DM patients with anemia, and T2DM and anemia were independently associated with LA phasic function. Deleterious interaction between LA function and LV function would happen in T2DM patients with or without anemia. Timely and effective monitoring and management of both LA and LV function will benefit T2DM patients.
Study context
- Population
- T2D patients with or without anemia and sex-matched controls, enrolled June 2015 to September 2022
- Participants
- 68 / 177 / 73
- Exposure
- T2D with anemia vs T2D without anemia vs controls
- T2DM with anemian = 68
- T2DM without anemian = 177
- Controlsn = 73reference
- Outcome
- LV and LA function (CMR)
Methodological detailscardiac magnetic resonance, sex-matched controls
- Cardiac magnetic resonance
- Sex-matched controls
Main finding
As reported in the abstract
- Left ventricular (LV) global longitudinal peak strain (GLPS) significantly declined from T2D with anemia to T2D without anemia to controls
- p < 0.001
- Left atrial (LA) volumetric function and strain significantly impaired in T2D with anemia vs the other groups
- all p < 0.05
Observational data: associations, not effects.
Further findings
Independent associations of LV GLPS with LA phasic strains (multivariate linear regression)
- LA reservoir strain, β
- 0.465
- LA conduit strain, β
- 0.450
- LA pump strain, β
- 0.360
- P
- all p < 0.05
- LA global conduit strain, total LA ejection fraction (LAEF) and active LAEF independently associated with LV GLPS and LVEF
- In addition to age, estimated glomerular filtration rate (eGFR), hemoglobin (Hb) and HbA1c
Baseline characteristics
- T2D with anemia older, with higher heart rate, higher creatinine, lower eGFR and lower Hb vs controls and T2D without anemia
- all p < 0.05
Original publication
Left atrioventricular interaction and impaired left atrial phasic function in type 2 diabetes mellitus patients with or without anemia: a cardiac magnetic resonance study. Cardiovasc Diabetol. Published 13 July 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →