Large (>4 cm) Intrathyroidal Encapsulated Well-Differentiated Follicular Cell-Derived Carcinoma Without Vascular Invasion May Have Negligible Risk of Recurrence Even When Treated with Lobectomy Alone
Authors' conclusion
Large intrathyroidal encapsulated well-differentiated thyroid carcinoma without vascular invasion follow an extremely indolent clinical course with negligible risk of recurrence.
Study context
- Population
- Patients with large (>4 cm) encapsulated well-differentiated thyroid carcinoma without vascular invasion, extrathyroidal extension, high-grade histology or other risk factors, resected 1995–2021
- Participants
- 88 patients
- Outcome
- Risk of nodal metastasis at initial resection, DFS and DSS
Main finding
As reported in the abstract
median follow-up 4.8 years (IQR 3.2-9.7 years)
Nodal metastasis at primary resection (all classic-type papillary thyroid carcinoma (PTC))
5 patients
Recurrence (local, regional or distant) in entire cohort, incl. lobectomy alone without radioactive iodine (RAI)
0
10-year disease-free survival (DFS)
100%
10-year disease-specific survival (DSS)
100%
Observational data: associations, not effects.
Further findings
Treatment
- Lobectomy/hemithyroidectomy alone
- 32 (36%)
- No RAI
- 55 (62%)
Histotype
- Follicular carcinoma
- 18 (21%)
- Oncocytic (Hurthle cell) carcinoma
- 8 (9%)
- PTC
- 62 (70%)
Original publication
Large (>4 cm) Intrathyroidal Encapsulated Well-Differentiated Follicular Cell-Derived Carcinoma Without Vascular Invasion May Have Negligible Risk of Recurrence Even When Treated with Lobectomy Alone. Thyroid. Published 18 April 2023. doi:10.
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