Role of the Degree of Vascular Invasion in Predicting Prognosis of Follicular Thyroid Carcinoma
Authors' conclusion
Our study results may enable us to stratify the prognosis of FTC more accurately by combining the histologic subtype with the degree of VI ≥2, aged ≥55 years, and tumor size >40 mm.
Study context
- Population
- Patients with follicular thyroid carcinoma (FTC) confirmed by surgical specimens at Ito Hospital, January 2005 to December 2014
- Participants
- 474 patients
- Exposure
- FTC histologic subtypes and degree of vascular invasion as prognostic factors
- Minimally invasive FTCn = 140
- Encapsulated angio-invasive FTCn = 260
- Widely invasive FTCn = 74
- Outcome
- DFS and distant metastasis-free survival
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
10-year DFS (M0 FTC) · 10 years
P < 0.001
- Independent negative prognostic factors for disease-free survival (DFS) (multivariate): age ≥55 years, HR
- 2.204 (95% CI, 1.223-3.969; P = .009)
- Histologic subtype, HR
- 2.068 (95% CI, 1.064-4.021; P = .032)
- Vascular invasion (VI) of ≥2, HR
- 6.814 (95% CI, 3.157-14.710; P < .001)
- Tumor size >40 mm, HR
- 2.014 (95% CI, 1.089-3.727; P = .026)
Observational data: associations, not effects.
Further findings
Independent negative prognostic factors for DFS (multivariate analysis)
- Aged ≥55 years: HR
- 2.204 (95% CI 1.223-3.969; P = .009)
- Histologic subtype: HR
- 2.068 (95% CI 1.064-4.021; P = .032)
- VI of ≥2: HR
- 6.814 (95% CI 3.157-14.710; P < .001)
- Tumor size >40 mm: HR
- 2.014 (95% CI 1.089-3.727; P = .026)
- Multivariate analysis
Original publication
Role of the Degree of Vascular Invasion in Predicting Prognosis of Follicular Thyroid Carcinoma. J Clin Endocrinol Metab. Published 25 November 2023. doi:10.
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